Diovan (Valsartan) Diovan 320 mg – A new antagonist (blocker), angiotensin II, was created to meet needs in the best antihypertensives, than those that exist today. Combining high efficiency, excellent tolerability, ease of use and no significant interactions with other medications, Diovan can rightly be considered the drug of first choice for the treatment of essential hypertension.
Diovan is absorbed from the gastrointestinal tract unchanged affects receptors, a small part of it undergoes metabolism, and the main – is excreted unchanged. Diovan is not a prodrug. Diovan is rapidly absorbed from the gastrointestinal tract and peak plasma concentrations achieved after about two hours after ingestion.
Period poluraspredeleniya Diovan at least 1 hour and the final half-life – about 9 hours. Pharmacokinetics Diovan does not change with repeated daily doses.
Diovan Diovan 320 mg undergoes minimal metabolism. After oral administration, approximately 30% of the drug excreted in urine and 70% – in the bile. Effectiveness Diovan not significantly altered, if taken with food.
Pharmacological Effects Diovan 320 mg:
Peripheral vasodilator, has a hypotensive effect. Specific blocker of AT1 receptors of angiotensin II, does not inhibit ACE, no effect on total cholesterol, triglyceride, glucose and uric acid in the blood. Beginning of the effect observed at 2 h after administration, maximum – after 4-6 h duration of action – more than 24 hours after the regular intake of maximum reduction in blood pressure occurs within 2-4 weeks. None syndrome “undo” the sudden discontinuation.
Indications Diovan 320 mg:
Hypertension. Chronic heart failure (II-IV class NYHA) – including against a combined reception with cardiac glycosides, diuretics, ACE inhibitors and beta-blockers.
Contraindications Diovan 320 mg:
Hypersensitivity, pregnancy, laktatsii.C caution. Biliary cirrhosis, biliary tract obstruction, renal insufficiency (creatinine clearance <10 mL / min), hyponatremia, renal artery stenosis (bilateral or single kidney).
Side effects Diovan 320 mg:
Headache, dizziness, fatigue, insomnia, diarrhea, abdominal pain, nausea, increased activity of liver transaminases, cough, rhinitis, sinusitis, pharyngitis, viral infections, interstitial pneumonia, neutropenia, anemia, decreased hematocrit, hyperkalemia, weakness, pain back pain, arthralgia, edema, skin rash, decreased libido, hypercreatininemia; embryotoxicity. Overdose. Symptoms: decreased blood pressure. Treatment: gastric lavage, IV 0.9% solution of NaCl.
Special instructions Diovan 320 mg:
Before treatment, shall adjust the content of Na + in blood and / or BCC. When renovascular hypertension requires regular monitoring of urea and creatinine in blood. In the case of pregnancy during treatment with the drug should be discontinued. With careful use by persons engaged in activities requiring increased attention and speed of motor and mental reactions.
Interaction Diovan 320 mg:
Potassium-sparing diuretics, drugs K +, salts containing K +, enhances development of hyperkalemia, diuretics – the hypotensive effect.
